James Doherty Selected Research

zuranolone

1/2022	A phase 1 double-blind, placebo-controlled study of zuranolone (SAGE-217) in a phase advance model of insomnia in healthy adults.
1/2022	Patient-reported health-related quality of life from a randomized, placebo-controlled phase 2 trial of zuranolone in adults with major depressive disorder.
2/2021	Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study.
1/2021	Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.
1/2020	SAGE-217, A Novel GABAA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.

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James Doherty Research Topics

Disease

5	Postpartum Depression (Post-Natal Depression) 01/2021 - 01/2017
2	Wounds and Injuries (Trauma) 01/2022 - 07/2007
2	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022 - 01/2017
2	Major Depressive Disorder (Major Depressive Disorders) 01/2022 - 01/2020
2	Neoplasms (Cancer) 02/2019 - 09/2018
1	Headache (Headaches) 01/2022
1	Vascular System Injuries 01/2022
1	Fatigue 01/2022
1	Tremor (Tremors) 02/2021
1	Burns 01/2021
1	Pancreatitis 01/2021
1	Confusion (Bewilderment) 01/2021
1	Encephalitis (Encephalitis, Rasmussen) 01/2020
1	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 01/2020
1	Memory Disorders (Memory Loss) 01/2020
1	Triple Negative Breast Neoplasms 02/2019
1	Pain (Aches) 01/2017
1	Sleepiness 01/2017
1	Sinus Tachycardia 01/2017
1	Dizziness (Lightheadedness) 01/2017
1	Tension-Type Headache (Tension Headache) 01/2017
1	Mood Disorders (Mood Disorder) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 05/2013
1	Tauopathies 05/2013
1	Opioid-Related Disorders (Opiate Addiction) 03/2009
1	Fever (Fevers) 01/2005
1	Critical Illness (Critically Ill) 01/2005
1	Lung Injury 07/2002
1	Meconium Aspiration Syndrome 07/2002
1	Seizures (Absence Seizure) 06/2002
1	Epilepsy (Aura) 06/2002

Drug/Important Bio-Agent (IBA)

5	zuranoloneIBA 01/2022 - 01/2020
3	Pharmaceutical PreparationsIBA 02/2019 - 03/2009
3	brexanoloneIBA 01/2019 - 01/2017
2	Tuberculin (PPD)IBA 01/2021 - 01/2017
2	Pregnanolone (Allopregnanolone)IBA 01/2017 - 01/2017
1	nasIBA 02/2021
1	Dopamine (Intropin)FDA LinkGeneric 02/2021
1	Dopamine Agents (Dopaminergic Agents)IBA 02/2021
1	insulin receptor-related receptor (IRR)IBA 01/2021
1	Phencyclidine (Angel Dust)IBA 01/2020
1	AntibodiesIBA 01/2020
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020
1	Antineoplastic Agents (Antineoplastics)IBA 02/2019
1	DNA (Deoxyribonucleic Acid)IBA 02/2019
1	Biological ProductsIBA 09/2018
1	Progesterone FDA LinkGeneric 01/2017
1	Hormones (Hormone)IBA 01/2017
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2017
1	Glycogen Synthase (Synthase I)IBA 05/2013
1	Proteins (Proteins, Gene)FDA Link 05/2013
1	Opiate AlkaloidsIBA 03/2009
1	Morphine (MS Contin)FDA LinkGeneric 03/2009
1	AntipyreticsIBA 01/2005
1	Peptides (Polypeptides)IBA 07/2002
1	Endothelin-1 (Endothelin 1)IBA 07/2002
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 06/2002
1	Anticonvulsants (Antiepileptic Drugs)IBA 06/2002

Therapy/Procedure

4	Therapeutics 02/2021 - 06/2002
1	Resuscitation 01/2022
1	Tourniquets 01/2022
1	Ambulatory Care (Outpatient Care) 01/2021
1	First Aid (Aids, First) 01/2021
1	Artificial Respiration (Mechanical Ventilation) 07/2007